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Iminosugars and Relatives as Antiviral and Potential Anti-infective Agents

P. Greimel, J. Spreitz, A.E. St├╝tz and T.M. Wrodnigg

Abstract:
Iminosugars have emerged in the literature during mid-1960s as synthetic compounds. Around the same time, the first examples were found in Nature and their interesting enzyme inhibitory properties were recognised. Due to their powerful interference with glycohydrolases (glycosidases) as well as glycosyltransferases, quite a few representatives exhibit notable biological activities. These range from anti-diabetic, insect antifeedant, nematicidal, plant growth regulating to immunomodulating, anti-cancer as well as in selected cases anti-infective properties. The latter will be the focus of the following survey.