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Lipase catalyzed resolution of bicyclic building blocks for leukotriene synthesis: Advantages of organic media.

Spreitz, J.; Grobbauer, R.; Griengl, H.; Faber, K.

Racemic bromohydroxybicycloheptanones I (R = Me, Ph) were conveniently resolved with lipase using CH2:CH2OAc as acyl donor and solvent. Both enantiomers were obtained in >96% enantiomeric excess